Bigelow’s publicized dealings with the ITAR regime is somewhat representative, but only the beginning.

ITAR, as constituted, essentially makes anything remotely related to spaceflight into restricted information. This obviously kills foreign sales of hardware, even to friendly nations. Beyond that, it impairs domestic collaboration. Interchange about completely civilian projects between American companies can’t go by email, lest some “technical data” be hijacked by eavesdroppers, creating an illegal export. Don’t tell your mother what you do because she might tell someone else, who might tell someone else, who might be a “foreign person”, who might well be a US citizen, thereby creating an illegal export.

Try presenting a paper at a conference these days. Good luck getting it past the corporate ITAR review process. No sensible company would dare let anyone write a significant paper, for fear of the ITAR thicket. Corporations are cowed because the ITAR regs are so vague but the punishments can be so extreme. No one is going to take a chance.
Curiously, the only people who can present anything significant are government employees, who are somewhat insulated form the ITAR insanity. There’s sort of a limit to what the ITAR enforcerment regime can do to them.

Many fields are stagnating in the US because nobody in any other country (even Canadians) will collaborate with a US citizen. Instead of becoming part of a significant international effort we are restricted to our own little block, while everyone else moves ahead.